Therapy & Management |
The efficacy of various drugs, such as sulfonylureas, biguanides and thiazolidinediones has not systematically been investigated, although they have been used to control blood glucose levels in patients with lipodystrophies. Insulin is commonly given to control hyperglycemia. Extremely high doses of insulin are often required to control levels of blood glucose. In such cases, concentrated preparation of insulin containing 500 units/ml can be helpful. What are the treatments available to improve insulin sensitivity?
Treatment is based on improving glucose control and preventing complications, especially cardiovascular disease. Diet is a mainstay of treatment along with exercise and weight loss. A low calorie diet reduces insulin resistance in days even before much weight loss takes place. Ten to twenty pounds (5-10 kg) substantially helps glycemic control and a loss of 16% of body weight Improves glucose metabolism by a 100%.
Therapy for High Blood Cholesterol and Triglycerides
Management of Lipodystrophy Cosmetic disfigurement due to fat loss is a major cause of concern for patients. Besides fat loss and excessive muscular appearance and hirsutism (increased body hair), dark colour pigmentation and thickening of the skin in the neck, armpits, groin and the trunk due to acanthosis nigricans may pose cosmetic problems. Diabetes is usually severe, and may produce short and long-term complications, such as kidney disease, retinal (eye) disease, heart disease and neuropathy (nerve damage). Hypertriglyceridemia (high levels of blood fats) may cause acute pancreatitis (acute pancreatic injury with severe abdominal pain) and can potentially further contribute to early-onset coronary heart disease. Cosmetic Management
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